For the majority of what is called church today, being despised(looked down on) and rejected by men is not known by leadership or "christians" in general. Yet, this is exactly how Scripture describes the experience of a disciple, a true believer following and learning from our Lord and Master Jesus Christ.

"He is despised and rejected by men, a man of sorrows and acquainted with grief. And we hid, as it were, our faces from Him; He was despised and we did not esteem Him."

The high calling of men means to be highly esteemed by men, yet the high calling of God will never be highly esteemed amongst men. The words of our Lord Jesus should be more than enough to convince us. Just listen to Him:

"Blessed are you when men hate you, and when they exclude you, and revile you, and cast out your name as evil, for the Son of Man's sake. Rejoice in that day and leap for joy! For indeed your reward is great in heaven, for in like manner their fathers did to the prophets....but,.. Woe to you when all men speak well of you, for so did their fathers to the false prophets." Luke 6:22-23,26

If we are serious about following in the steps of our Lord Jesus then we must die to all desire for the applause and recognition of men. If we are hoping to be accepted by men then we are simply not yet serious disciples of Christ!

Consider this: our entire salvation was dependent on Jesus' willingness to be despised and rejected by men. He chose to be a nobody when He is the SOMEBODY!
"He was in the world and the world was made by Him and
the world did not know Him" then "He came to His own and His own did not receive Him" (John 1:10-11)

In a time when much of what is called the church is looking for such recognition, we see Jesus who "made Himself of no reputation, taking the form of a bondservant.." (Phil.2:7) And the Spirit says to every disciple of Christ, "Let this mind be also in you.." (Phil.2:5)

If the King of the Universe suffered such rejection by men, then why should I expect to be highly esteemed and accepted by this same world.

"Therefore Jesus also, that He might sanctify the people with His own blood, suffered outside the gate. Therefore let us go forth to Him, outside the camp, bearing His reproach." Hebrews 13:12-13